ENC may refer to:
The Eastern Nazarene College, a college of the liberal arts and sciences located in Quincy, Massachusetts
Eastern North Carolina, the eastern third, the coastal plains, of the state of North Carolina
The effective number of codons, a measure to study codon usage biases in genes
An electronic navigational chart, a database for use with an electronic chart display and information system (ECDIS)
A European Nations' Cup, one of three competitions in either field hockey or rugby
Equivalent Noise Charge, the number of electrons one would have to collect from a silicon sensor in order to create a signal equivalent to the noise of this sensor.
The ENC Network, a PhD and Masters training network of seven European Neuroscience Centers
An external node classifier used with Puppet_(software) configuration management software is an executable that can be queried and return information on hosts to be managed.